Journal
BIOLOGICAL PSYCHIATRY
Volume 59, Issue 8, Pages 762-772Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.08.030
Keywords
schizophrenia; event-related potentials; mismatch negativity; N2; P3; cognition
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Funding
- NIMH NIH HHS [MH-41646, MH-00537, MH-41960] Funding Source: Medline
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Background: Deficits in amplitude of auditory event-related potentials (ERP) indexing preattentive, automatic (mismatch negativity, MMN) and controlled, attention-dependent (N2, P3) auditory information processing have been well described in chronic schizophrenia. Normal MMN, but deficient N2 and P3 have been reported in first-episode patients. No study has investigated these ERPs concurrently in first-episode patients; thus, reported differences in MMN, N2 and P3 generation may reflect differences in patient samples rather than genuine differences in abnormal generation of these ERPs. Methods: We recorded MMN, N2 and P3 in 26 first-episode patients, 25 recent-onset patients within 1.5 to 5 years after first transmission, 25 chronic patients and 39 healthy control. Results: Recent-onset and chronic, but not first-episode patients showed reduced MMN. Howeverm, among first-episode patients those with low premorbid educationa; achievement demonstrated significantly reduced MMN. All patient groups showed pronounced N2 deficits and, to a variable extent, abnormalities in P3 generation. Conclusions: Abnormalities in N2 and P3 generation appear to reflect premorbid neuropathology, whereas MMN deficits may index bith ongoing disease processes associated with illness progression as well as premorbid neurocognitive impairment. ERPs may provide tools to assess static and progressive neuropathology in schizophrenia. These findings need confirmation in longitudinal studies.
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