Journal
FEBS LETTERS
Volume 580, Issue 9, Pages 2306-2310Publisher
WILEY
DOI: 10.1016/j.febslet.2006.03.044
Keywords
histone methylation; historic acetylation; histone modification; mass spectrometry; Edman; Trypanosoma brucei
Funding
- NIAID NIH HHS [AI21729, AI50614] Funding Source: Medline
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To start to understand the role of chromatin structure in regulating transcription in trypanosomes, we analyzed covalent modifications on the four core histones of Trypanosoma brucei. We found unusually few modifications in the N-terminal tails, which are abundantly modified in other organisms and whose sequences, but not composition, are highly divergent in trypanosomes. In contrast, the C-terminal region of H2A appears to be hyper-acetylated. Surprisingly, the N-terminal alanines of H2A, H2B, and H4, were mono-methylated, a modification that has not been described previously for histones. Possible functions and evolutionary explanations for these unusual histone modifications are discussed. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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