Journal
FEBS LETTERS
Volume 580, Issue 9, Pages 2178-2182Publisher
WILEY
DOI: 10.1016/j.febslet.2006.03.026
Keywords
pannexin farnily; gap junction proteins; retina; retinal ganglion cells; gene expression; antibody
Funding
- NEI NIH HHS [R01 EY014232, P30-EY014801, R01-EY14232] Funding Source: Medline
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Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR. Both pannexins showed robust expression across the retina with predominant accumulation in the retinal ganglion cells (RGCs). In concordance, immuno-histochemical analysis showed accumulation of the Panx1 protein in RGCs, amacrine, horizontal cells and their processes. Two Panx1 isoforms were detected: a ubiquitously expressed 58 kDa protein, and a 43 kDa isoform that specifically accumulated in the retina and brain. Our results indicated that Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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