Journal
NEURON
Volume 50, Issue 2, Pages 277-289Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.03.042
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Funding
- NIDCD NIH HHS [DC-00304] Funding Source: Medline
- NINDS NIH HHS [NS-039518, NS-038253] Funding Source: Medline
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TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals. To test the in vivo roles of TRPA1, we generated a mouse in which the essential exons required for proper function of the Trpa1 gene were deleted. Knockout mice display behavioral deficits in response to mustard oil, to cold (similar to 0 degrees C), and to punctate mechanical stimuli. These mice have a normal startle reflex to loud noise, a normal sense of balance, a normal auditory brainstem response, and normal transduction currents in vestibular hair cells. TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons.
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