Journal
NEUROREPORT
Volume 17, Issue 6, Pages 593-597Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200604240-00008
Keywords
FGF-2; learned helplessness; neurogenesis; stress
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Funding
- NIDA NIH HHS [DA13159, DA016004] Funding Source: Medline
- NIMH NIH HHS [MH50497] Funding Source: Medline
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The controllability of stressors modulates many of the consequences of stressor exposure. Here, we used immunohistochemistry to examine neural progenitor cell proliferation and survival and basic fibroblast growth factor-2 in the hippocampus of male rats after controllable or uncontrollable tailshock. A series of identical tailshocks were delivered to yoked pairs of rats. One rat could terminate shocks to both rats of the pair. Reductions in neural progenitor cells were observed at 1-2 days and at 28 days in rats exposed to uncontrollable shock. Controllable shock produced an increase in fibroblast growth factor-2 in the dentate gyrus and CAI 2 h after stress and in the dentate gyrus 24 h after stress. Thus, stressor controllability modulates stress-induced decreases in neurogenesis and increases in fibroblast growth factor-2. (c) 2006 Lippincott Williams & Wilkins.
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