Journal
TETRAHEDRON LETTERS
Volume 47, Issue 17, Pages 2925-2928Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.02.111
Keywords
Sonogashira coupling; cross-coupling; secondary alkyl halide; palladium; N-heterocyclic carbene
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A palladium-carbene catalyzed Sonogashira coupling of unactivated alkyl bromides with alkyl substituted alkynes is reported. For the first time, unactivated secondary alkyl halides were successfully employed in Sonogashira reactions. (c) 2006 Elsevier Ltd. All rights reserved.
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