Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 17, Pages 6676-6681Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0601752103
Keywords
adipose tissue; gene expression; subcutaneous; intraabdominal
Categories
Funding
- NICHD NIH HHS [K12 HD027748, HD027748] Funding Source: Medline
- NIDDK NIH HHS [DK60837, R01 DK060837, K08DK064906, K08 DK064906, R01 DK033201, R01 DK33201] Funding Source: Medline
Ask authors/readers for more resources
Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available