Journal
ORGANIC LETTERS
Volume 8, Issue 9, Pages 1893-1896Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol060457z
Keywords
-
Categories
Funding
- NCI NIH HHS [CA31845] Funding Source: Medline
Ask authors/readers for more resources
The first member of a new class of five-membered B-ring analogs of bryostatin has been synthesized and tested for its ability to bind and translocate protein kinase C (PKC). This synthesis extends the utility of our previously introduced macrotransacetalization strategy to the formation of five-membered dioxolane B-ring analogs. This analog exhibits potent, single-digit nanomolar affinity to PKC and selectively translocates novel PKC isozymes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available