4.8 Article

Construction of β-haloenamides via direct copper-promoted coupling of lactams with 2-chloro and 2-bromo vinyliodides

Journal

ORGANIC LETTERS
Volume 8, Issue 9, Pages 1779-1781

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol060093a

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Cu(I)-catalyzed coupling of lactams with (E)-2-chlorovinyliodides or (E)-2-bromovinyliodides produces the corresponding beta-haloenamides in moderate to excellent yields.

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