Journal
BIOLOGICAL PSYCHIATRY
Volume 59, Issue 9, Pages 812-815Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.09.022
Keywords
plasticity; sex differences; genetics; MRI; anatomy; stress
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Funding
- NIDA NIH HHS [R01 DA 016423] Funding Source: Medline
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Background- A frequent polymorphism of the brain-derived neurotrophic factor (BDNF) gene (val(66) met) has been suggested to modulate hippocampal neuronal plasticity and has been associated with, individual variations in emotional reactivity traits and episodic memory. Methods. The hippocampal formation was outlined in high-resolution anatomical magnetic resonance imaging (MRI) data in a sample of 36 healthy volunteers and compared between individuals as a function of the presence of the met-BDNF allele. Both whole-brain volume corrected and uncorrected data were tested for effects of genotypes sex, and age. Results: The met-BDNF allele was associated with an 11% reduction in The volume of the hippocampal formation. Conclusions: In spite of a relatively small sample size, The presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.
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