☆ 4.4 Article

The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica

INFECTION AND IMMUNITY (2006)

Get Full Text
Add to Collection

Journal

INFECTION AND IMMUNITY
Volume 74, Issue 5, Pages 3065-3067

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.5.3065-3067.2006

Keywords

-

Categories

Immunology Infectious Diseases

Funding

  1. NIAID NIH HHS [AI065619, R21 AI065619] Funding Source: Medline
  2. NIDDK NIH HHS [DK064750, R01 DK064750-01A1, R01 DK056160, R01 DK064750-04, R01 DK056160-05, R01 DK056160-02, P30 DK040561-11, R01 DK064750-02, R01 DK064750, P30 DK040561, R01 DK056160-03, DK05610, R01 DK056160-01, R01 DK064750-03, P30 DK040561-06, R01 DK056160-04] Funding Source: Medline

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.