Journal
PROTEIN SCIENCE
Volume 15, Issue 5, Pages 1193-1198Publisher
WILEY
DOI: 10.1110/ps.062092506
Keywords
tetratricopeptide repeat ( TPR); Hsp90; protein phosphatase 5 ( PP5); Vpu-binding protein/small glutamine-rich protein (UBP/SGT); ligand binding
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Tetratricopeptide repeat (TPR) domains bind specific peptide ligands and are thought to mediate protein-protein interactions in a variety of biological systems. Here we compare peptide ligand-binding by several different TPR domains. We present specific examples that demonstrate that TPR domains typically undergo little or no structural rearrangement upon ligand binding. Our data suggest that, contrary to a recent proposal, coupled folding and binding is not the common mechanism of ligand recognition by TPR domains.
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