Journal
BONE MARROW TRANSPLANTATION
Volume 37, Issue 10, Pages 955-959Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1705351
Keywords
major salivary glands; HPCT; Tc-99m-pertechnetate and gallium-67 scintigraphy
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Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with Tc-99m-pertechenate and Ga-67 in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of Tc-99m-pertechenate results did not demonstrate any functional differences between pre-versus post transplant periods. Results of the Ga-67 scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.
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