Journal
ACTA CYTOLOGICA
Volume 50, Issue 3, Pages 309-311Publisher
SCI PRINTERS & PUBL INC
DOI: 10.1159/000325959
Keywords
cervix neoplasms; mass screening; Papanicolaou smear; ThinPrep Pap Test
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Objective To compare the ThinPrep (R) Imaging System (Cytyc Corp., Boxborough, Massachusetts, U.S.A) to manual screening in the detection of cervical squamous epithelial lesion (SIL). Study Design A total of 27,525 manually screened ThinPrep Pap tests were compared with 27,725 imaged ThinPrep Pap tests for: (1) diagnostic rates of atypical squamous cells of undetermined significance; atypical squamous cells of undetermined significance, cannot rule out high grade SIL (ASC-H); low grade SIL and high grade SIL (HSIL); (2) ASC/SIL ratio; (3) high-risk HPV positivity for ASC; and (4) biopsy follow-up for ASC-H and HSIL. Results There were significant increases in the percentage of cytologic diagnoses in all categories with the imager. The ASC/SIL ratios of both groups were comparable. There was a significant decrease in HPV positivity in the imager group of ASC. Biopsy results confirmed a significant increase in the detection of HSIL in, both the ASC-H and HSIL groups of the imaged cohort. Conclusion The ThinPrep Imaging System. is significantly better than manual screening in the detection of cervical SIL.
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