Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 113, Issue 5, Pages 593-598Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-005-0350-0
Keywords
Parkinson's disease; oxidative stress; monoamine oxidase; antioxidant; neuroprotection; disulfide
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Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 mu M, IC-50 = 0.5 mu M) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.
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