Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 35, Issue 5, Pages 446-450Publisher
SPRINGER
DOI: 10.1007/s00249-006-0042-1
Keywords
cell biophysics; biological tissue; microscopy
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Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferroflulds can be enriched in tumour tissue and tumour cells.
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