Journal
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Volume 154, Issue 5, Pages 623-632Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/eje.1.02140
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We have reviewed the immunology of thyroid autoimmunity with special reference to the importance of B lymphocytes (B cells) in thyroidal and extrathyroidal Graves' disease (GD), thus providing a framework for the hypothesis that B cell depletion may be beneficial in GD. Additionally, after reviewing the efficacy and safety in other autoimmune diseases, we propose that treatment with the B cell-depleting agent Rituximab may become a clinically relevant treatment option in selected cases of GD, particularly when complicated with thyroid-associated ophthalmopathy.
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