4.4 Article

Bacteriocins Pep5 and epidermin inhibit Staphylococcus epidermidis adhesion to catheters

Journal

CURRENT MICROBIOLOGY
Volume 52, Issue 5, Pages 350-353

Publisher

SPRINGER
DOI: 10.1007/s00284-005-0152-5

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Pep5 and epidermin bacteriocins were tested on clinical strains of Staphylococcus epidermidis and S. aureus isolated from catheter-related infections. These bacteriocins were inhibitory to several isolates at a concentration of 640 activity units mL(-1). The ability of bacteriocins in inhibiting adhesion of S. epidermidis to silicone catheters was evaluated. When Pep5 and epidermin were added to in vitro catheter colonization experiments, there was a significant decrease in the cell number of S. epidermidis adhered to silicone catheters. Bacteriocins used to decrease bacterial attachment to medical devices may represent a novel strategy to control catheter-related infections.

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