Journal
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Volume 60, Issue 5, Pages 577-581Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1368-5031.2006.00920.x
Keywords
hypertension; renin; renin inhibitors
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Despite improvements in its detection and treatment, hypertension remains a significant public health problem worldwide. In recent years, many international hypertension societies and organisations have set increasingly rigorous blood pressure (BP) targets, with the aim of reducing cardiovascular complications, and this has in turn necessitated the use of more antihypertensive medications to reach these targets in individual patients. There is therefore an ongoing need to develop antihypertensive drugs with new mechanisms of action. Renin inhibitors represent a novel class of compounds which offer considerable promise as BP-lowering agents. Here, we review the rationale for renin inhibition as a therapeutic target and examine the preclinical and clinical evidence for the antihypertensive effectiveness of the renin inhibitors.
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