Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 55, Issue 5, Pages 967-973Publisher
WILEY
DOI: 10.1002/mrm.20892
Keywords
mRI; oxygen saturation; field mapping; jugular vein; phase imaging
Funding
- NCRR NIH HHS [RR02305] Funding Source: Medline
- NHLBI NIH HHS [R01HL68908] Funding Source: Medline
- NINDS NIH HHS [NS045839] Funding Source: Medline
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Monitoring of oxygen saturation in jugular venous blood gives an estimate of the balance of global oxygen delivery and cerebral oxygen consumption. We present a noninvasive approach to measure oxygen saturation in vivo in the internal jugular vein using MR susceptometry by exploiting the characteristic susceptibility of deoxyhemoglobin, and demonstrate the feasibility of performing such measurements in a group of subjects. We assessed the sensitivity of the method for detecting small changes in oxygen saturation by monitoring the variations observed during breath-holding and hypoventilation experiments. Unlike alternative methods, the susceptometric technique does not require calibration.
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