Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 10, Pages 1141-1148Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-005-5532-2
Keywords
congenital heart defects; genetics; cardiac development
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Funding
- NICHD NIH HHS [K08 HD001382] Funding Source: Medline
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Cardiovascular malformations are the most common type of birth defect and result in significant mortality worldwide. The etiology for the majority of these anomalies remains unknown. Advances in the characterization of the molecular pathways critical for normal cardiac development have led to the identification of numerous genes necessary for this complex morphogenetic process. This work has aided the discovery of an increasing number of single genes being implicated as the cause of human cardiovascular malformations. This review summarizes normal cardiac development and outlines the recent discoveries of the genetic causes of congenital heart disease.
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