4.4 Article

Synthesis of 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as potential anti-inflammatory agents

Journal

JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 43, Issue 3, Pages 709-718

Publisher

HETERO CORPORATION
DOI: 10.1002/jhet.5570430327

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Funding

  1. NCRR NIH HHS [G12 RR003020, G12 RR003020-25] Funding Source: Medline
  2. NIGMS NIH HHS [08111] Funding Source: Medline

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Fifteen novel 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydro- pyridine-5-carboxylic acid diethylamide (7, 15) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding 1-(substituted phenylcarbonyl/ sulfonylimino)-3-diethylcarbamoyl pyridinium. ylides (6, 14) in absolute ethanol.

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