Journal
MUSCLE & NERVE
Volume 33, Issue 5, Pages 691-693Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mus.20467
Keywords
cachexia; fatigue; muscle function; skeletal muscle
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CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle '' quality '' appears unaltered.
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