Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 8, Issue 3, Pages 344-349Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc050138j
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Study was made of the 1,3-dipolar cycloaddition of polymer-bound alkynes to azomethine imines generated in situ from N-aminopyridine iodides. Aromatization of the cycloadducts gives polymer-bound pyrazolo-pyridines that can be released from the resin as carboxylic acids with trifluoroacetic acid or as methyl esters with sodium methoxide.
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