Journal
BIOTECHNOLOGY LETTERS
Volume 28, Issue 10, Pages 687-695Publisher
SPRINGER
DOI: 10.1007/s10529-006-9045-3
Keywords
elastin-like polymers; genetic engineering; nanobiotechnology; protein-based polymers; smart polymers; tissue engineering
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The genetic engineering of protein-based polymers is a method that enables, in an easy way, the design of complex and highly functional macromolecules. As examples of this approach, different molecular designs are presented, with increasing degree of complexity, showing how the controlled increase in their complexity yields (multi)functional materials with more selected and sophisticated properties. The simplest designs show interesting properties already, but the adequate introduction of given chemical functions along the polymer chain provides an opportunity to expand the range of properties to enhanced smart behavior and self-assembly. Finally, examples are given where those molecular designs further incorporate selected bioactivities in order to develop materials for the most cutting edge applications in biomedicine and nano(bio)technology.
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