Journal
NATURE REVIEWS GENETICS
Volume 7, Issue 5, Pages 385-394Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1839
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Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest version of the family-based design - the transmission disequilibrium test - is well known, but the numerous extensions that broaden its scope and power are less widely appreciated. Family-based designs have unique advantages over population-based designs, as they are robust against population admixture and stratification, allow both linkage and association to be tested for and offer a solution to the problem of model building. Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies.
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