Journal
ULTRASONICS SONOCHEMISTRY
Volume 13, Issue 4, Pages 359-363Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2006.01.002
Keywords
insonation; reaction crystallization; sonocrystallization
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The action of power ultrasound in controlling the supersaturation, nucleation and crystal growth during the acid-base reaction crystallization of 7-amino-3-desacetoxy cephalosporanic acid (7-ACDA) has been investigated. The experimental results show that ultrasound can mix the reaction more efficiently and uniformly than conventional agitation methods. Insonation leads to the reduction of both the induction period and metastable zone width of the crystallization, so that the process of crystallization can be more efficiently controlled than without insonation. Agglomeration is also greatly reduced. Adjusting the ultrasonic parameters can modulate the crystal size and size distribution. The mechanism of the sonoprocess has been analyzed and comments are made on the potential applicability of sonication in large-scale crystallization practice. (C) 2006 Elsevier B.V. All rights reserved.
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