Health Utilities Index mark 3 demonstrated construct validity in a population-based sample with type 2 diabetes

Objective: To assess the cross-sectional construct validity of the Health Utilities Index mark 3 (HUI3) in type 2 diabetes using population health survey data. Study Design and Setting: Data used were from 5,134 adult respondents of Cycle 1.1 (2000-2001) of the Canadian Community Health Survey (CCHS) with type 2 diabetes. Analyses of covariance models were used to assess differences in overall and single-attribute HUI3 scores between groups hypothesized a priori to differ in HRQL. The association between health-care resource use (i.e., hospitalizations and physician and emergency room visits) and overall HUI3 scores was assessed using logistic regression models. Results: For overall HUI3 scores, clinically important and statistically significant differences were observed between all groups expected to differ in HRQL. Depression was the comorbidity associated with the largest deficit (-0.17; 95% confidence interval Cl = -0.22, -0.12), followed by stroke (-0.15; 95% Cl = -0.21, -0.10) and heart disease (-0.08; 95% Cl = -0.11, -0.05). Insulin use and comorbidities were associated with clinically important deficits in pain. Overall HUI3 scores were significantly predictive of all three categories of health-care resource use. Conclusion: Observed differences between groups contribute further evidence of the construct validity of the HUI3 in type 2 diabetes. (C) 2006 Elsevier Inc. All rights reserved.