Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1763, Issue 5-6, Pages 542-548Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.04.006
Keywords
mitochondria; electron microscopy; electron tomography; membrane topology; bioenergetics; cardiolipin
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Funding
- NCRR NIH HHS [P41 RR001219, RR01219] Funding Source: Medline
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Three-dimensional images of mitochondria provided by electron tomography reveal that the micro-compartments (cristae) defined by the inner membrane are connected to the periphery of this membrane by narrow tubular junctions, which likely restrict diffusion. The tomograms also strongly suggest that inner membrane topology represents a balance between membrane fusion and fission processes. The hypothesis being developed is that inner membrane topology is a regulated property of mitochondria. This review summarizes the evidence about how inner membrane shape influences mitochondrial function and, conversely, what is known about the factors that determine this membrane's topology. (c) 2006 Elsevier B.V All rights reserved.
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