Journal
VETERINARY JOURNAL
Volume 171, Issue 3, Pages 500-503Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2004.12.005
Keywords
cow; progesterone; embryo; pregnancy; interferon
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We have investigated the effects of the timing of progesterone supplementation on early embryo development in mature, non-lactating Holstein-Friesian cows. Animals were inseminated 72 h (day 1) and 96 h following prostaglandin injection and were either left as untreated controls (n = 6) or received progesterone supplementation from either days 5 to 9 (early; n = 6) or from days 12 to 16 (late; n = 6). Daily plasma samples were collected until day 16, when cows were slaughtered and reproductive tracts recovered and flushed to collect embryos and to measure interferon-T activity. Both early and later progesterone supplementation resulted in marked increases in plasma progesterone (P < 0.01). Early, but not late, progesterone supplementation resulted in a fourfold increase in trophoblast length (P < 0.01) and a sixfold increase in uterine concentration of interferon-T (P < 0.05). The results demonstrate that progesterone supplementation during the postovulatory rise, but not later in the luteal phase, increases embryo development and interferon-c production. (c) 2004 Elsevier Ltd. All rights reserved.
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