Journal
MAGNETIC RESONANCE IMAGING
Volume 24, Issue 4, Pages 343-348Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2005.12.023
Keywords
single-voxel proton spectroscopy; ultrahigh magnetic field; BOLD; lactate
Funding
- NCRR NIH HHS [P41RR08079] Funding Source: Medline
- NINDS NIH HHS [R01NS38672] Funding Source: Medline
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Proton magnetic resonance spectroscopy (H-1-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of H-1-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 mu mol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (+/- 0.2 mu mol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz. (c) 2006 Elsevier Inc. All rights reserved.
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