Journal
JOURNAL OF NEUROCHEMISTRY
Volume 97, Issue 3, Pages 607-618Publisher
WILEY
DOI: 10.1111/j.1471-4159.2006.03810.x
Keywords
apoptosis; glutamate; immunology; specific protein-1; transcription; translation
Categories
Funding
- NIA NIH HHS [R01 AG017498, R01 AG017498-04] Funding Source: Medline
- NINDS NIH HHS [R01NS041593, R01 NS046439, R01 NS046439-03, R01 NS041593-04A1, R01 NS041593, R01NS046439] Funding Source: Medline
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Nuclear factor kappa B (NF kappa B) is a dynamically modulated transcription factor with an extensive literature pertaining to widespread actions across species, cell types and developmental stages. Analysis of NF kappa B in a complex environment such as neural tissue suffers from a difficulty in simultaneously establishing both activity and location. Much of the available data indicate a profound recalcitrance of NF kappa B activation in neurons, as compared with most other cell types. Few studies to date have sought to distinguish between the various combinatorial dimers of NF kappa B family members. Recent research has illuminated the importance of these problems, as well as opportunities to move past them to the nuances manifest through variable activation pathways, subunit complexity and target sequence preferences.
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