Journal
DRUG DISCOVERY TODAY
Volume 11, Issue 9-10, Pages 391-404Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2006.03.001
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Bacterial resistance continues to develop and pose a significant threat, both in hospitals and, more recently, in the community. A focus on other therapeutic areas by the larger pharmaceutical companies has left a shortfall in the pipeline of novel antibacterials. Recently, many new structures have been studied by structure-genomics initiatives, delivering a wealth of targets to consider. Using the tools of structure-based design, antibacterial discovery must exploit these targets to accelerate the process of drug discovery.
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