Journal
ARCHIVES OF NEUROLOGY
Volume 63, Issue 5, Pages 649-654Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archneur.63.5.649
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Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hop for disease-modifying therapies in Parkinson disease.
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