Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1757, Issue 5-6, Pages 459-466Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2006.02.005
Keywords
uncoupling protein; mitochondria; purine nucleotide; fatty acid; thermogenesis; membrane potential; proton conductance
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Funding
- NIA NIH HHS [R01 AG1440] Funding Source: Medline
- NINDS NIH HHS [R01 NS41908] Funding Source: Medline
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Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs. (c) 2006 Elsevier B.V. All rights reserved.
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