Journal
TUBERCULOSIS
Volume 86, Issue 3-4, Pages 268-272Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2006.01.006
Keywords
tuberculosis; antibodies; infection model; BCG
Categories
Ask authors/readers for more resources
The effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration to mice of human gamma globulins. This treatment of mice inhibited BCG colonization of the lungs (p < 0.01). A similar inhibitory effect was observed after infection of mice with gamma globutin opsonized BCG organisms (p < 0.01). These results are relevant for the development of new strategies for the control and treatment of tuberculosis. (c) 2006 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available