Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 37, Issue 3, Pages 279-286Publisher
ELSEVIER
DOI: 10.1016/j.supflu.2005.09.005
Keywords
drug nanoparticles; supercritical fluid; RESOLV; stabilization; ibuprofen
Categories
Ask authors/readers for more resources
Rapid expansion of a supercritical solution into a liquid solvent (RESOLV) was applied to the nanosizing of ibuprofen particles in aqueous suspension. When the rapid expansion was into neat water, the initially formed nanoscale ibuprofen particles agglomerated into large aggregates. Various water-soluble polymers of different molecular weights were added to the aqueous receiving medium in RESOLV as stabilization agent for the produced nanoparticle suspension, and their effects on the properties of the harvested ibuprofen nanoparticles were evaluated. A conclusion is that the selection of stabilization agent in RESOLV may also be used to alter the sizes and morphology of the nanosized drug particles. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available