Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 127, Issue 5, Pages 497-499Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.01.020
Keywords
indoleamine 2,3-dioxygenase; immunosenescence; longevity
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Indoleamine 2,3-dioxygenase (IDO), an enzyme degrading tryptophan (trp) to kynurenine (kyn), suppresses T cell activity. Ageing of the immune system, immunosenescence, includes a decline in T cell function. We therefore sought to establish whether IDO activity is involved in immunosenescence and whether it predicts mortality in aged subjects. We measured kyn/trp, reflecting IDO activity, in 284 nonagenarians and 309 blood donor controls. IDO activity was significantly higher in nonagenarians compared with controls and IDO activity at study entry predicted subsequent mortality in nonagenarians. Thus, increased IDO activity might be a mechanism involved in the decline of T cell responses in immunosenescence. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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