Journal
ANALYTICAL BIOCHEMISTRY
Volume 352, Issue 1, Pages 87-96Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2006.02.025
Keywords
ginsenoside Rb-1; ill vivo metabolites; rat; LC-MS-MS
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Liquid chromatography coupled with mass spectrometry and tandem mass spectrometry has been applied to investigate the in vivo metabolism of ginsenoside Rb-1 in rat. Both positive electrospray ionization mass spectrometry and negative electrospray ionization mass spectrometry were used to identify the Rb, and its metabolites in rat plasma, urine, and feces samples. Oxygenation and deglycosylation were found to be the major metabolic pathways of Rb, in rat. A total of nine metabolites were detected in urine and feces samples collected after intravenous and oral administration. Deglycosylated metabolism of Rb, generated other ginsenosides as the major metabolites. such as Rd, Rg(3) or F-2, Rh-2, or C-K. This result indicates that the ginsenoside Rb-1 has many pharmacological activities and could be used as a prodrug. (c) 2006 Elsevier Inc. All rights reserved.
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