Journal
MAYO CLINIC PROCEEDINGS
Volume 81, Issue 5, Pages 693-703Publisher
ELSEVIER SCIENCE INC
DOI: 10.4065/81.5.693
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Funding
- NCI NIH HHS [CA 62242, CA 107476] Funding Source: Medline
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The spectrum of plasma cell disorders Is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow In the absence of end-organ damage. Waldenstrom macroglobulinemia typically Involves an ontogenically less mature lymphoplasmacytic bone marrow cell and Is characterized by secretion of a monoclonal IgM protein. Solitary plasmacytoma Is the only known potentially curable plasma cell disorder. Finally, AL (Immunoglobulin light chain) amyloidosis and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome are disorders characterized by low tumor burden but profound multisystemic disease. Updated diagnostic criteria for these disorders, risk stratification models to determine prognosis, and the current management of these diverse entities are discussed In this review.
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