Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 65, Issue 5, Pages 674-676Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2005.037895
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Background: C reactive protein (CRP) is a known indicator of inflammation. Serum CRP is often raised in patients with inflammatory conditions. Objective: To determine whether individuals make antibodies to CRP and whether this might affect serum CRP concentrations. Methods: An enzyme linked immunosorbent assay was developed for the detection of antibodies to CRP. Specificity of the reaction was determined by inhibition of the reaction. Results: Sera from 413 patients were tested and 25 were found to be positive, particularly in patients with rheumatic diseases. Levels of anti-CRP did not correlate with serum CRP levels. Conclusions: The presence of low CRP levels may not reflect the presence of antibodies to CRP.
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