Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 3, Issue 5, Pages 384-389Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017806776611971
Keywords
titanium; reductive amination; ketones; secondary amines; imines; diastereoselectivity
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An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.
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