Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 26, Issue 3, Pages 222-232Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-006-9010-x
Keywords
adolescent women; uterine cervix; biologic covariates; cytokines; mucosal immunity
Categories
Funding
- NCI NIH HHS [2 R01 CA87905-01, 2 R01 CA51323-11A1, R01 CA087905, R01 CA051323, R37 CA051323] Funding Source: Medline
- NCRR NIH HHS [5 M01 RR-01271] Funding Source: Medline
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Measurements of mucosal immune parameters in the uterine cervix are potentially influenced by numerous factors, including infections, endogenous and exogenous hormones, semen, and nicotine and its metabolites in cervical mucus. The objective of this study was to examine correlates of immunoregulatory cytokine mRNA expression in cervical cytology samples in a cross-sectional design. Samples, collected at study entry by cervical cytology brush from 368 women aged 13-21 enrolled in a longitudinal study of the natural history of human papillomavirus (HPV) infection, were tested by quantitative RT-PCR for expression of IFN-gamma, IL-4, IL-10, and IL-12. In a multivariate analysis, elevated levels of IFN-gamma, IL-10, and IL-12 were significantly (p < 0.05) associated with several variables, including current C. trachomatis infection, recent intercourse, and current oral contraceptive pill use. Suppressed IL-4 and IL-10 levels were associated with cigarette smoking within the last 24 h. Time since last menstrual period did not affect any of the cytokines; in a substudy of weekly cytokine variability, however, IL-10 showed a non-significant trend toward higher levels around the time of menstruation.
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