Journal
DEVELOPMENTAL CELL
Volume 10, Issue 5, Pages 549-561Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2006.04.008
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA102702] Funding Source: Medline
Ask authors/readers for more resources
Apoptosis, a form of programmed cell death, is executed by a family of zymogenic proteases known as caspases, which cleave an array of intracellular substrates in the dying cell. Many proapoptotic stimuli trigger cytochrome c release from mitochondria, promoting the formation of a complex between Apaf-1 and caspase-9 in a caspase-activating structure known as the apoptosome. In this review, we describe knockout and knockin studies of apoptosome components, elegant structural and biochemical experiments, and analyses of the apoptosome in various cancers and other disease states, all of which have provided new insight into this critical locus of apoptotic control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available