Journal
NATURE CLINICAL PRACTICE NEUROLOGY
Volume 2, Issue 5, Pages 276-282Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpneuro0172
Keywords
cerebrovascular disease; dementia; impaired glucose tolerance; metabolic syndrome; neuropathy
Categories
Funding
- NCRR NIH HHS [M01 RR 00064] Funding Source: Medline
- NIDDK NIH HHS [DK064814] Funding Source: Medline
- NINDS NIH HHS [NS40458] Funding Source: Medline
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Stroke and peripheral neuropathy are recognized neurological complications of diabetes. Increasing epidemiological evidence also implicates the prediabetic state of impaired glucose tolerance (IGT) as a risk factor for cerebrovascular events and peripheral neuropathy. Data linking IGT to cognitive decline or deficits, however, are less robust. IGT is one component of metabolic syndrome, together with central obesity, hypertension, hypertriglyceridemia and reduced HDL. Each component of metabolic syndrome is an independent risk factor for stroke, but hyperglycemia might be more important than other components in the pathogenesis of neuropathy. Goal-driven diet and exercise regimens, together with pharmacological treatment of hyperlipidemia and hypertension, reduce stroke risk, but the effect of these interventions oil neuropathy has not been fully explored.
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