Journal
GENOMICS
Volume 87, Issue 5, Pages 673-677Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2006.01.007
Keywords
mouse; LDL receptors; limb development; mutation
Funding
- NCRR NIH HHS [P40 RR01183] Funding Source: Medline
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Positional cloning of two recessive mutations of the mouse that cause polysyndactyly (dan and mdig-Chr 2) confirmed that the gene encoding MEGF7/LRP4, a member of the low-density lipoprotein receptor family, plays an essential role in the process of digit differentiation. Pathologies observed in the mutant mice provide insight into understanding the function(s) of LPR4 as a negative regulator of the Wnt-beta-catenin signaling pathway and may help identify the genetic basis for common human disorders with similar phenotypes. (c) 2006 Elsevier Inc. All rights reserved.
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