Journal
NATURE IMMUNOLOGY
Volume 7, Issue 5, Pages 482-488Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1319
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Funding
- NIAID NIH HHS [AI47822, T32 AI007290] Funding Source: Medline
- NIDDK NIH HHS [DK060000, DK56339, DK07056] Funding Source: Medline
- NIGMS NIH HHS [GM37734] Funding Source: Medline
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Prevailing knowledge dictates that naive ab T cells require activation in lymphoid tissues before differentiating into effector or memory T cells capable of trafficking to nonlymphoid tissues. Here we demonstrate that CD8(+) recent thymic emigrants (RTEs) migrated directly into the small intestine. CCR9, CCL25 and alpha(4)beta(7) integrin were required for gut entry of CD8(+) RTEs. After T cell receptor stimulation, intestinal CD8+ RTEs proliferated and acquired a surface phenotype resembling that of intraepithelial lymphocytes. CD8(+) RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid organs. These studies challenge the present understanding of naive alpha beta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces.
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