Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 54, Issue 5, Pages 682-686Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.682
Keywords
biscoumarins; HIV-1 integrase; inhibitor
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Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.
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