Journal
PHYTOMEDICINE
Volume 13, Issue 5, Pages 310-317Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2005.01.016
Keywords
flavonoids; macrophages; prostaglandin E-2; cyclooxygenase; anti-inflammatory effects
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A study of the structure-activity relations of the inhibitory effect of flavonoids on lipopolysaccharide (LPS)-induced prostaglandin production was carried out via a comparative examination of 39 flavonoids and related compounds. A comparison of the subclasses showed that flavones were most effective, followed by flavanones. Flavonols were less effective than those two groups. These results suggest that the C2-C3 double-bond and 4-oxo functional group of the C-ring are important factors for the high inhibition activities. Flavonoids showed the strongest inhibitory effect on the expression of Cox-2 protein. These results help to explain part of the reason for the pharmacological efficacy of flavonoids as anti-inflammatory compounds. (c) 2005 Elsevier GmbH. All rights reserved.
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