Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 9, Pages 2492-2495Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.094
Keywords
incrustoporine; furanones; antifungal; mechanism of action; flow cytometry; Candida
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The mechanism of action of the antifungal agent 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans was investigated by flow cytometry, using propidium iodide, DiBAC(4)(3), and FUN-1 as the fluorescent dyes. A related but less active agent, together with amphotericin B and fluconazole, was tested in parallel for comparison of the results. The incrustoporine derivative was found to have it potent fungicidal activity on C. albicans, resulting in damage of cell membrane. (C) 2006 Elsevier Ltd. All rights reserved.
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